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特任助教 Szandor Simmons

Academic Education and Scientific Experiences

04/2013 – present               Assistant Professor

Osaka University, WPI Immunology Frontier Research Center & Graduate School of Medicine, Department of Immunology and Cell Biology, Prof. Masaru Ishii, Osaka, Japan.

09/2010 – 03/2013            Postdoctoral Scientist (Kishimoto Foundation Fellow)

Osaka University, WPI Immunology Frontier Research Center, Laboratory of Cellular Dynamics, Prof. Masaru Ishii, Osaka, Japan.

04/2010 – 08/2010            Postdoctoral Fellow

Max Planck Institute for Infection Biology, Department of Lymphocyte Development, Prof. Fritz Melchers, Berlin, Germany.

04/2010                             Ph.D. / Dr.-Ing.

Technical University of Berlin, Faculty III – Process Sciences, Berlin, Germany.

10/2005 – 03/2010            Ph.D.-Student

Max Planck Institute for Infection Biology, Department of Lymphocyte Development, Prof. Fritz Melchers, Berlin, Germany.

09/2005                             Diploma of Biotechnology / Dipl.-Ing. Biotechnology

Technical University of Berlin, Faculty III – Process Sciences

10/2002 - 09/2005             Diploma-Studies in Medical Biotechnology / Diploma-Student (Immunology)

Technical University of Berlin, Faculty III – Process Sciences / University of Basel, Biocentrum, Prof. Fritz Melchers, Basel, Switzerland.

 

Professional Memberships

2012 – present                             Member of the Japanese Society of Immunology - JSI.

2007 – present                             Member of the German Immunological Society - DGFI.

 

Publications:

Research Articles:

1.         Ito K, Matsui Y, Kihara A, Morimoto J, Kurotaki D, Kanayama M, Maeda N, Simmons S, Ishii M, Sheppars D, Uede T. Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress by inducing S1P secretion. PNAS. 2014 Feb. 25;111(8):3080-5. DOI: 10.1073/pnas.1311022111. Epub 2014 Feb. 10.

2.         Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S,  Ikuta K. Characterization of the Interleukin-15 Niche in Primary and Secondary Lymphoid Organs In Vivo. PNAS. 2014 Feb. 4;111(5):1915-20. DOI: 10.1073/pnas.1318281111. Epub 2014 Jan. 21.

3.         Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Kawasaki S, Zaffalon A, Nagata-Takaoka M, Fullwood NJ, Sano S, Itami S, Ishii M, Jensen KB, Barrandon Y, Kinoshita S. Lrig1 controls the corneal stem cell homeostasis through negative regulation of a Stat3-dependent inflammatory pathway. The Journal of Clinical Investigation. 2014 Jan 2;124(1):385-97. DOI: 10.1172/JCI71488. Epub 2013 Dec 9.

4.         Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F. Envirnoments of B cell development. Immunology Letters. 2014 Jan-Feb;157(1-2):60-3. DOI: 10.1016/j.imlet.2013.11.011. Epub 2013 Nov 24.

5.         Knoll M, Simmons S, Bouquet C, Gruen J, Melchers F. miR-221 redirects precursor B cells to the bone marrow and regulates their residence. European Journal of Immunology. 2013 Sep;43(9):2497-506. DOI: 10.1002/eji.201343367. Epub 2013 Jul 8.

6.         Simmons S, Knoll M, Drewell C, Wolf I, Mollenkopf HJ, Bouquet C, Melchers F. Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development. Blood. 2012 Nov 1;120(18):3688-98. DOI: 10.1182/blood-2012-03-414821. Epub 2012 Aug 27.

7.         Knoll M, Yanagisawa Y, Simmons S, Engels N, Wienands J, Melchers F, Ohnishi K.. The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. Journal of Immunology. 2012 Jun 15;188(12):6010-7. DOI: 10.4049/jimmunol.1200071. Epub 2012 May 7.

8.         Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. The Journal of Clinical Investigation. 2012 Apr 2;122(4):1416-26. doi: 10.1172/JCI60746. Epub 2012 Mar 12.

Review Articles:

1.         Simmons S, Ishii M. Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. Archivum Immunologiae et Therapiae Experimentalis. 2014 Apr;62(2):103-15. DOI: 10.1007/s00005-013-0264-8. Epub 2013 Nov 26.

Books:

1.         Simmons S, Analysis of Hematopoietic Plasticity and B-Cell Development in Progenitors with Regulable hPax5 Expression. mbv, Mensch-&-Buch-Verlag. 2010