Publications
2023
1) Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y, Okuzaki D, Morii E, Emoto N, Shintan Y, Ishii M. (2023) In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nat. Commun., 14:143.
2) Yari S, Kikuta J, Shigyo H, Okuzaki D, Furusawa Y, Minoshima M, Kikushi K & Ishii M. (2023) JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors. Inflamm. Regen., 43(1):18
3) Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu YC, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara H, Ishii M. (2023) Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat. Commun., 14:4417.
2022
1) Yoshida G, Kawabata T, Takamatsu H, Saita S, Nakamura S, Nishikawa K, Fujiwara M, Enokidani Y, Yamamuro T, Tabata K, Hamasaki M, Ishii M, Kumanogoh A, Yoshimori T. (2022) Degradation of the Notch intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis. Autophagy, 13:1-10.
2) Uenaka M, Yamashita E, Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, Ishii M. (2022) Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nat. Commun., 13:1066.
3) Narazaki A, Shimizu R, Yoshihara T, Kikuta J, Sakaguchi R, Tobita S, Mori Y, Ishii M, Nishikawa K. (2022) Monocyte regulation by physiological oxygen tension perturbation in bone marrow. Sci. Rep. 12(1):3497.
4) Kaneko C, Tsutsui H, Ozeki K, Honda M, Haraya K, Narita Y, Kamata-Sakurai M, Kikuta J, Tabo M, Ishii M. (2022) In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody. Sci. Rep. 12(1):4907.
5) Matsui T, Iwasa A, Mimura M, Taniguchi S, Sudo T, Uchida Y, Kikuta J, Morizono H, Horii R, Motoyama Y, Morii E, Ohno S, Kiyota Y, Ishii M. (2022) Label-free multiphoton excitation imaging as a promising diagnostic tool for breast cancer. Cancer Sci., 113(8):2916-2925.
6) Hasegawa T, Ishii M. (2022) Pathological Osteoclasts and Precursor Macrophages in Inflammatory Arthritis. Front Immunol.
7) Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. (2022) Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion. Inflamm Regen. 42(1):17.
8) Scheele CLGJ, Herrmann D, Yamashita E, Celso CL, Jenne CN, Oktay MH, Entenberg D, Friedl P, Weigert R, Meijboom FLB, Ishii M, Timpson P and Rheen JV. (2022) Multiphoton intravital microscopy of rodents. Nat Rev Methods Primers. 2 : 89.
9) Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y, Okuzaki D, Morii E, Emoto N, Shintan Y, Ishii M. (2022) In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nat. Commun., 14: 143.
2021
1) Tsuchiya A, Takeuchi S, Iwasawa T, Nojiri S, Watanabe T, Ogawa M, Yoshida T, Fujiki K, Koui Y, Kido T, Yoshioka Y, Fujita M, Kikuta J, Itoh T, Takamura M, Shirahige K, Ishii M, Ochiya T, Miyajima A, Terai S. (2021) Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis. NPJ Regen. Med., 6(1):19.
2) Morimoto A, Kikuta J, Nishikawa K, Sudo T, Uenaka M, Furuya M, Hasegawa T, Hashimoto K, Tsukazaki H, Seno S, Nakamura A, Okuzaki D, Sugihara F, Ninomiya A, Yoshimura T, Takao-Kawabata R, Matsuda H, Ishii M. (2021) SLPI is a critical mediator that controls PTH-induced bone formation. Nat. Commun., 2(1):2136.
3) Tsukazaki H, Kikuta J, Ao T, Morimoto A, Fukuda C, Tsuda E, Minoshima M, Kikuchi K, Kaito T, Ishii M. (2021) Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation. Bone, 152: 116095.
4) Lok LSC, Walker JA, Jolin HE, Scanlon ST, Ishii M, Fallon PG, McKenzie ANJ, Clatworthy MR. (2021) Group 2 innate lymphoid cells exhibit tissue-specific dynamic behaviour during type 2 immune responses. Front. Immunol., 12: 711907.
5) Momiuchi Y, Motomura Y, Suga E, Mizuno H, Kikuta J, Morimoto A, Mochizuki M, Otaki N, Ishii M, Moro K. (2021) Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF, and IL-13. Int. Immunol., 33(11):573-585.
6) Nishikawa K, Seno S, Yoshihara T, Narazaki A, Sugiura Y, Shimizu R, Kikuta J, Sakaguchi R, Suzuki N, Takeda N, Semba H, Yamamoto M, Okuzaki D, Motooka D, Kobayashi Y, Suematsu M, Koseki H, Matsuda H, Yamamoto M, Tobita S, Mori Y, Ishii M. (2021) Osteoclasts adapt to physioxia perturbation through DNA demethylation. EMBO Rep., 22(12): e53035.
7) Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T. (2021) Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cell. Mol. Immunol., 18(6):1437-1449.
8) Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. (2021) Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis. Immunol. Med., 30, 1-5.
9) Hasegawa T, Kikuta J, Ishii M. (2021) Imaging of bone and joints in vivo: pathological osteoclastogenesis in arthritis. Int. Immunol., 33(12): 679-686.
10) Ao T, Kikuta J, Ishii M.(2021) The effects of vitamin D on immune system and inflammatory diseases. Biomolecules, 11:1624
11) Takeuchi S, Tsuchiya A, Iwasawa T, Nojiri S, Watanabe T, Ogawa M, Yoshida T, Fujiki K, Koui Y, Kido T, Yoshioka Y, Fujita M, Kikuta J, Itoh T, Takamura M, Shirahige K, Ishii M, Ochiya T, Miyajima A, Terai S.(2021) Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis. npj Regenerative Medicine, 6.
2020
1) Kim H, Takegahara N, Walsh MC, Middleton SA, Shirakawa J, Ueda J, Fujihara Y, Ikawa M, Ishii M, Kim J, Choi Y. (2020) IgSF11 regulates osteoclast differentiation through phosphorylation of pyruvate kinase M2. Bone Res., 8:5.
2) Nishizawa S, Kikuta J, Seno S, Kajiki M, Tsujita R, Mizuno H, Sudo T, Ao T, Matsuda H, Ishii M. (2020) Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo. J Pharmacol Sci, published online.
3) Hashimoto K, Kaito T, Furuya M, Seno S, Okuzaki D, Kikuta J, Tsukazaki H, Matsuda H, Yoshikawa H, Ishii M. (2020) In vivo dynamic analysis of BMP-2-induced ectopic bone formation. Sci Rep, published online.
4) Ao T, Kikuta J, Sudo T, Uchida Y, Kobayashi K, Ishii M. (2020) Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation. Int. Immunol., published online.
5) Hasegawa T, Ishii M. (2020) Visualizing bone tissue in homeostatic and pathological conditions. Proc Jpn Acad Ser B Phys Biol Sci, 96 (2), 43-49.
6) Morimoto A., Kikuta J., Ishii M. (2020) Intravital multiphoton microscopy as a novel tool in the field of immunopharmacology. Pharmacol Ther., 206:107429.
7) Morimatsu M, Yamashita E, Seno S, Sudo T, Kikuta J, Mizuno H, Okuzaki D, Motooka D, Ishii M. (2020) Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway. Inflamm Regen., 6;40:15.
8) Hashimoto R, Minoshima M, Kikuta J, Yari S, Bull SD, Ishii M, Kikuchi K. (2020) An Acid Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities. Angew Chem Int Ed Engl., published online.
9) Hasegawa T, Kikuta J, Sudo T, Yamashita E, Seno S, Takeuchi T, Ishii M. (2020) Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo. Sci Rep., 10;10(1):13480.
10) Matsui T, Tamoto R, Iwasa A, Mimura M, Taniguchi S, Hasegawa T, Sudo T, Mizuno H, Kikuta J, Onoyama I, Okugawa K, Shiomi M, Matsuzaki S, Morii E, Kimura T, Kato K, Kiyota Y, Ishii M. (2020) Nonlinear optics with near-infrared excitation enable real-time quantitative diagnosis of human cervical cancers. Cancer Res., published online.
11) Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T. (2020) Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cell Mol Immunol., published online.
12) Hashimoto R, Minoshima M, Kikuta J, Yari S, Bull SD, Ishii M, Kikuchi K. (2020) An Acid-Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities. Angew Chem Int Ed Engl., published online.
13) Nishikawa K & Ishii M (2020) Novel method for gain-of-function analyses in primary osteoclasts using a non-viral gene delivery system. J Bone Miner Metab., published online.
14) Sudo T, Motomura Y, Okuzaki D, Hasegawa T, Yokota T, Kikuta J, Ao T, Mizuno H, Matsui T, Motooka D, Yoshizawa R, Nagasawa T, Kanakura Y, Moro K, Ishii M. (2020) Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions J. Exp. Med., 3;218(5):e20200817.
2019
1) Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K. (2019) GPR31-dependent dendrite protrusion of intestinal CX3CR1(+) cells by bacterial metabolites. Nature. 566(7742):110-114.
2) Hasegawa T, Kikuta J, Ishii M. (2019) Imaging the Bone-Immune Cell Interaction in Bone Destruction. Front Immunol. 10:596.
3) Minoshima M, Kikuta J, Omori Y, Seno S, Suehara R, Maeda H, Matsuda H, Ishii M, Kikuchi K. (2019) In Vivo Multicolor Imaging with Fluorescent Probes Revealed the Dynamics and Function of Osteoclast Proton Pumps. ACS Cent Sci. 5(6):1059-1066.
4) Simmons S, Sasaki N, Umemoto E, Uchida Y, Fukuhara S, Kitazawa Y, Okudaira M, Inoue A, Tohya K, Aoi K, Aoki J, Mochizuki N, Matsuno K, Takeda K, Miyasaka M, Ishii M. (2019) High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node. Elife. 8. pii: e41239.
5) Morimoto A, Kikuta J, Ishii M. (2019) Intravital multiphoton microscopy as a novel tool in the field of immunopharmacology. Pharmacol Ther. Nov 2:107429.
6) Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M. (2019) Identification of a novel arthritis associated osteoclast precursor macrophage regulated by FoxM1. Nat Immunol 20(12):1631-1643.
2018
1) Furuya M, Kikuta J, Fujimori S, Seno S, Maeda H, Shirazaki M, Uenaka M, Mizuno H, Iwamoto Y, Morimoto A, Hashimoto K, Ito T, Isogai Y, Kashii M, Kaito T, Ohba S, Chung Ui, Lichtler AC, Kikuchi K, Matsuda H, Yoshikawa H, Ishii M. (2018) Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo. Nat. Commun., 9(1):300.
2) Mizuno H, Kikuta J, Ishii M. (2018) In vivo live imaging of bone cells. Histochem. Cell Biol., 149(4): 417-422.
3) Ueda Y, Ishiwata T, Shinji S, Arai T, Matsuda Y, Aida J, Sugimoto N, Okazaki T, Kikuta J, Ishii M, Sato M. (2018) In vivo imaging of T cell lymphoma infiltration process at the colon. Sci Rep. 8(1):3978.
4) Matsuura R, Miyagawa S, Kikuta J, Ishii M, Sawa Y. (2018) Intravital imaging of the heart at the cellular level using two-photon microscopy. Methods Mol. Biol, 1763: 145-151.
5) Matsumoto S, Kikuta J, Ishii M. (2018) Intravital imaging of liver cell dynamics. Methods Mol. Biol, 1763: 137-143
6) Kikuta J, Ishii M. (2018) Bone imaging: Osteoclast and osteoblast dynamics. Methods Mol. Biol, 1763: 137-143
7) Matsuura Y, Kikuta J, Kishi Y, Hasegawa T, Okuzaki D, Hirano T, Minoshima M, Kikuchi K, Kumanogoh A, Ishii M. (2018) In vivo visualization of different modes of action of biologic DMARDs inhibiting osteoclastic bone resorption. Ann. Rheum. Dis., 77(8):1219-1225.
8) Sakaguchi Y, Nishikawa K, Seno S, Matsuda H, Takayanagi H, Ishii M. (2018) Roles of enhancer RNAs in RANKL-induced osteoclast differentiation identified by genome-wide Cap-analysis of gene expression using CRISPR/Cas9. Sci. Rep., 14(1): 7504.
9) Kikuta J, Shirazaki M, Sudo T, Mizuno H, Morimoto A, Suehara R, Minoshima M, Kikuchi K, Ishii M. (2018) Dynamic analyses of the short-term effects of different bisphosphonates using intravital two-photon microscopy. JBMR Plus, 2(6): 362-366.
10) Inaki M, Hatori R, Kikuta J, Ishii M, Matsuno K, Honda H. (2018) Chiral cell sliding drives left-right asymmetric organ twisting. eLife, in press.
11) Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, Suda T. (2018) Folliculin regulates osteoclastogenesis through metabolic regulation. J. Bone Miner. Res., 33(10):1785-1798.
12) Tanaka Y, Sabharwal L, Ota M, Nakagawa I, Jiang JJ, Arima Y, Ogura H, Okochi M, Ishii M, Kamimura D, Murakami M. (2018) Presenilin 1 regulates NF-κB activation via association with breakpoint cluster region and casein kinase II. J. Immunol., 201(8):2256-2263.
13) Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA. (2018) Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches. Proc. Natl. Acad. Sci. USA, 115(43): E10137-E10146.
14) Matsuura R, Miyagawa S, Fukushima S, Goto T, Harada A, Shimozaki Y, Yamaki K, Sanami S, Kikuta J, Ishii M, Sawa Y. (2018) Intravital imaging with two-photon microscopy reveals cellular dynamics in the ischeamia-reperfused rat heart. Sci. Rep., 8(1): 15991.
2017
1) Matsui T, Mizuno H, Sudo T, Kikuta J, Haraguchi N, Ikeda JI, Mizushima T, Yamamoto H, Morii E, Mori M, Ishii M. (2017) Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions. Sci Rep., 31;7(1):6959.
2) Miyachi Y, Tsuchiya K, Komiya C, Shiba K, Shimazu N, Yamaguchi S, Deushi M, Osaka M, Inoue K, Sato Y, Matsumoto S, Kikuta J, Wake K, Yoshida M, Ishii M, Ogawa Y. (2017) Roles of cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and glucose intolerance. Cell Rep., 18: 2766-2779.
3) Kon S, Ishibashi K, Katoh H, Kitamoto S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Sato T, Duchen M, Shirai T, Tanaka S, Narumi R, Morita T, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Fujita Y. (2017) Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat. Cell Biol, 19: 530-541.
4) Ishii M. (2017) Immunology provides a great success for treating systemic autoimmune diseases – a perspective on immunopharmacology – IUPHAR Review 23. Br. J. Pharmacol, 174(13):1875-1880.
5) Shigeta H, Mashita T, Kikuta J, Seno S, Takemura H, Ishii M, Matsuda H. (2017) Bone marrow cavity segmentation using Graph-cuts with wavelet-based texture feature. J. Bioinform. Comput. Biol., 15(5): 1740004.
6) Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. (2017) 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J. Allergy Clin. Immunol., (17) 32949-4.
7) Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, Ishii M, Tsukita S, Katayama I. (2017) Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis. J. Invest., Dermatol., (17)33356-0.
8) Ishii M. (2017) Imaging of inflammation and regeneration – a novel trend dissecting dynamic features of biological phenomena in vivo. Inflamm. Regen. 37: 26.
2016
1) Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Ochi S, Penninger JM , Katayama I, Inohara I, Ishii M. (2016) Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Mol Cell Biol, 6(11):1610-20.
2) Takegahara N, Kim H, Mizuno H, Sakaue-Sawano A, Miyawaki A, Tomura M, Kanagawa O, Ishii M, Choi Y. (2016) Involvement of receptor activator of nuclear factor kappa-B ligand-induced incomplete cytokinesis in polyploidization of osteoclasts. J. Biol. Chem., 291: 3439-54.
3) Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. (2016) Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife, 5, e10561.
4) Kojima S, Inoue T, Kikuta J, Furuya M, Koga A, Fujimoto T, Ueta M, Kinoshita S, Ishii M, Tanihara H. (2016) Visualization of intravital immune cell dynamics after conjunctival surgery using multiphoton microscopy, Invest. Ophtalmol. Vis. Res., 57: 1207-12.
5) Maeda H, Kowada T, Kikuta J, Furuya M, Shirazaki M, Mizukami S, Ishii M*, Kikuchi K*. (2016) Real-time intravital imaging of pH variation associated with cell osteoclast activity and motility using designed small molecular probe. Nature Chem. Biol., 12(8):579-85.
6) Otani K, Naito Y, Sakaguchi Y, Seo Y, Takahashi Y, Kikuta J, Ogawa K, Ishii M. (2016) Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo. Sci. Rep., 6:30689.
7) Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. Prickle1 promotes focal adhesion disassembly in cooperation with CLASP-LL5β complex in migrating cells. J. Cell Sci., 129(16):3115-29.
8) Ishii M. (2016) Intravital imaging technology reveals immune system dynamics in vivo. Allergol. Int., 65(3): 225-227.
2015
1) Sekimoto R, Fukuda S, Maeda N*, Tsushima Y, Matsuda K, Mori T, Nakatsuji H, Nishizawa H, Kishida K, Kikuta J, Maijima Y, Funahashi T, Ishii M*, Shimomura I. (2015) Visualized macrophage dynamics and significance of S100A8 in obese fat. Proc. Natl. Acad. Sci. USA, 112: E2058-66.
2) Sano H, Kikuta J, Furuya M, Kondo N, Endo N, Ishii M. (2015) Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo. Bone, 74:134-9.
3) Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M. (2015) RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. J. Biol. Chem., 290(10):6326-37.
4) Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y. (2015) Transplanted bone marrow-derived circulating PDGFRa+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J. Immunol., 194(4):1996-2003.
5) Nishikawa K, Iwamoto Y, Kobayashi Y, Katsuoka F, Kawaguchi S, Tsujita T, Nakamura T, Kato S, Yamamoto M, Takayanagi H, Ishii M. (2015) Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway. Nature Med., 21(3):281-7.
6) Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Taylor S, Oh M-J, Levitan I, Wang G, Qian F, Ye RD, Carnegie GK, Zhao Y, Xu J. (2015) Moesin provides global inhibition for neutrophil chemotaxis. J. Exp. Med., 212(2):267-80.
7) Manes NP, Angermann BR1, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A. (2015) Targeted proteomics-driven computational modeling of macrophage S1P chemosensing. Mol. Cell. Proteomics, 14(10): 2661-81.
8) Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. (2015) Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J. Exp. Med. 212(11):1931-46.
9) Onodera T, Fukuhara A, Jang MH, Shin J, Aoi K, Kikuta J, Otsuki M, Ishii M, Shimomura I (2015) Adipose tissue macrophages induce PPARγ-high FOXP3+ regulatory T cells. Sci. Rep. 5:16801.
10) Ueta M, Koga A, Kikuta J, Yamada K, Kojima S, Ishii M, Kinoshita S. (2015) Intravital imaging of the cellular dynamics of LysM-positive cells in a corneal suture mouse model. Br. J. Opthalmol., 100: 432-5.
11) Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T. (2015) Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep., 6:18738.
12) Tiligada E, Ishii M, Riccardi C, Spedding M, Simon H-U, Teixeira MM, Cuervo MLC, Holgate ST, Levi-Schaffer F. (2015) The expanding role of immunopharmacology - IUPHAR Review X. Br. J. Pharmacol., 172(17): 4217-27.
2014
1) Simmons, Ishii M. (2014) Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. Arch. Immunol. Ther. Exp., 62(2); 103-115.
2) Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood N, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S. (2014) Lrig1 controls corneal maintenance through the Stat3-dependent inflammatory pathway. J. Clin. Invest, 124(1):385-97.
3) Nishikawa K, Iwamoto Y, Ishii M. (2014) Development of an in vitro culture method for stepwise differentiation of mouse embryonic stem cells and induced pluripotent stem cells into mature osteoclasts. J. Bone Miner. Metab., 32(3): 331-336.
4) Cuia G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K. (2014) Characterization of the Interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc. Natl. Acad. Sci. USA, 111(5):1915-20.
5) David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J. Biol. Chem., 289(10):6551-64.
6) Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. (2014) Integrin α9 on lymphatic endothelial cell regulates lymphocyte egress. Proc. Natl. Acad. Sci. USA, 118(8); 3080-3085.
7) Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A. (2014) A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J., 33(7): 702-18.
8) Rattanapak T, Birchall JC, Young K, Kubo A, Fujimori S, Ishii M, Hook S. (2014) Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS One, 9(2):e89503.
9) Matsui S, Murota H, Ono E, Kikuta J, Ishii M, Katayama I. (2014) Olopatadine hydrochloride restores histamine-induced impaired sweating. J. Dermatol. Sci., 74(3): 260-1.
10) Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. (2014) Generation of colonic IgA-secreting cells in the cecal patch. Nat. Commun., 5: 3704.
11) Hatori R, Ando T, Sasamura T, Nakazawa N, Nakamura M, Taniguchi K, Hozumi S, Kikuta J, Ishii M, Matsuno K. (2014) Left-right asymmetry is formed in individual cells by intrinsic cell chirality. Mech Dev., 133:146-62.
12) Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y. (2014) Filamin acts as a key regulator in epithelial defence against transformed cells. Nat. Commun., 5: 4428.
13) Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Umeshita K, Ishii H, Doki Y, Mori M, Ishii M. (2014) Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J. Biol. Chem., 289(34): 23786-23795.
14) Kikuta J, Ishii M. (2014) Intravital multiphoton microscopy for dissecting cellular dynamics in arthritic inflammation and bone destruction. Methods Mol. Biol.,1142: 1-10.
2013
1) Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M. (2013) Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. J. Immunol., 190(2):605-12.
2) Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamoto H, Doki Y, Mori M, Ishii H. (2013) Depletion of Jarid1b induces cellular senescence in human colorectal cancer. Int. J. Oncol., 42(4):1212-8.
3) Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. (2013) Dynamic visualization of RANKL and Th17-mediated osteoclast function. J. Clin. Invest., 123(2): 866-873.
4) Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci., 16(5):543-51.
5) Wienert S, Heim D, Kotani M, Lindequist B, Stenzinger A, Ishii M, Hufnagl P, Beil M, Dietel M, Denkert C, Klauschen F (2013) CognitionMaster: An Object-Based Image Analysis Framework. Diagn. Pathol., 8:34.
6) Ishii M, Kikuta J. (2013) Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. Biochim Biophys Acta, 1831(1), 223–227.
7) Kikuta J, Ishii M. (2013) Osteoclast migration, differentiation, and function: novel therapeutic targets for rheumatic diseases. Rheumatology, 52(2):226-34.
8) Ishii M, Fujimori S, Kaneko T, Kikuta J. (2013) Dynamic live imaging of bone: opening a new era with 'bone histodynametry'. J Bone Miner Metab, 31 (5): 507-511.
9) Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M (2013) S1P-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc. Natl. Acad. Sci. USA, 110(17): 7009-13.
10) Matsui S, Murota H, Takahashi A, Yang A, Lee J-B, Omiya K, Ohmi M, Kikuta J, Ishii M, Katayama I. (2014) Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J. Invest. Dermatol., 134(2): 326-34.
11) Rattanapak T, Birchall J, Young K, Ishii M, Meglinski I, Rades T, Hook S. (2013) Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using optical coherence tomography and two-photon microscopy. J. Control. Release, 172(3):894-903.
12) Kano Y, Konno M, Ohta K, Haraguchi N, Nishikawa S, Kagawa Y, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Ishii M, Mizohata E, Inoue T, Mori M, Doki Y, Ishii H. (2013) Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Mol Clin Oncol. 1(4):753-757.
13) Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M. (2013) Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One, 8(12): e83629.
Main publication list before 2012
1) Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M*, Mochizuki N* The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122: 1416-1426, 2012.
2) Kikuta J, Iwai K, Saeki Y, Ishii M. S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. Rheumatol. Int. 31: 967-969, 2011.
3) Kowada T, Kikuta, J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K. In vivo fluorescence imaging of bone-resorbing osteoclasts. J. Am. Chem. Soc., 33(44):17772-17776, 2011.
4) Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J. Exp. Med., 207: 2793-2796, 2010.
5) Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature, 458: 524-528, 2009.
6) Klauschen F, Ishii M, Qi, H., Bajénoff, M., Egen, J.G., Germain, R.N., Meier-Schellersheim, M. Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data. Nature Protoc., 4:1305-1311, 2009.
