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発表論文

2017年度

1) Matsui T, Mizuno H, Sudo T, Kikuta J, Haraguchi N, Ikeda JI, Mizushima T, Yamamoto H, Morii E, Mori M, Ishii M. (2017) Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions. Sci Rep., 31;7(1):6959. 

2) Miyachi Y, Tsuchiya K, Komiya C, Shiba K, Shimazu N, Yamaguchi S, Deushi M, Osaka M, Inoue K, Sato Y, Matsumoto S, Kikuta J, Wake K, Yoshida M, Ishii M, Ogawa Y. (2017) Roles of cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and glucose intolerance. Cell Rep., 18: 2766-2779.

3) Kon S, Ishibashi K, Katoh H, Kitamoto S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Sato T, Duchen M, Shirai T, Tanaka S, Narumi R, Morita T, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Fujita Y. (2017) Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat. Cell Biol, 19: 530-541.

4) Ishii M. (2017) Immunology provides a great success for treating systemic autoimmune diseases – a perspective on immunopharmacology – IUPHAR Review X. Br. J. Pharmacol, published online.


2016年度

1) Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Ochi S, Penninger JM , Katayama I, Inohara I, Ishii M. (2016) Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Mol Cell Biol,  6(11):1610-20.

2) Takegahara N, Kim H, Mizuno H, Sakaue-Sawano A, Miyawaki A, Tomura M, Kanagawa O, Ishii M, Choi Y. (2016) Involvement of receptor activator of nuclear factor kappa-B ligand-induced incomplete cytokinesis in polyploidization of osteoclasts. J. Biol. Chem., 291: 3439-54.

3) Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. (2016) Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife, 5, e10561.

4) Kojima S, Inoue T, Kikuta J, Furuya M, Koga A, Fujimoto T, Ueta M, Kinoshita S, Ishii M, Tanihara H. (2016) Visualization of intravital immune cell dynamics after conjunctival surgery using multiphoton microscopy, Invest. Ophtalmol. Vis. Res., 57: 1207-12.

5) Maeda H, Kowada T, Kikuta J, Furuya M, Shirazaki M, Mizukami S, Ishii M*, Kikuchi K*. (2016) Real-time intravital imaging of pH variation associated with cell osteoclast activity and motility using designed small molecular probe. Nature Chem. Biol., 12(8):579-85.

6) Otani K, Naito Y, Sakaguchi Y, Seo Y, Takahashi Y, Kikuta J, Ogawa K, Ishii M. (2016) Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo. Sci. Rep., 6:30689.

7) Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. Prickle1 promotes focal adhesion disassembly in cooperation with CLASP-LL5β complex in migrating cells. J. Cell Sci., 129(16):3115-29.

8) Ishii M. (2016) Intravital imaging technology reveals immune system dynamics in vivo. Allergol. Int., 65(3): 225-227.


2015年度

1) Sekimoto R, Fukuda S, Maeda N*, Tsushima Y, Matsuda K, Mori T, Nakatsuji H, Nishizawa H, Kishida K, Kikuta J, Maijima Y, Funahashi T, Ishii M*, Shimomura I. (2015) Visualized macrophage dynamics and significance of S100A8 in obese fat. Proc. Natl. Acad. Sci. USA, 112: E2058-66.

2) Sano H, Kikuta J, Furuya M, Kondo N, Endo N, Ishii M. (2015) Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo. Bone, 74:134-9.

3) Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M. (2015) RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. J. Biol. Chem., 290(10):6326-37.

4) Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y. (2015) Transplanted bone marrow-derived circulating PDGFRa+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J. Immunol., 194(4):1996-2003.

5) Nishikawa K, Iwamoto Y, Kobayashi Y, Katsuoka F, Kawaguchi S, Tsujita T, Nakamura T, Kato S, Yamamoto M, Takayanagi H, Ishii M. (2015) Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway. Nature Med., 21(3):281-7.

6) Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Taylor S, Oh M-J, Levitan I, Wang G, Qian F, Ye RD, Carnegie GK, Zhao Y, Xu J. (2015) Moesin provides global inhibition for neutrophil chemotaxis. J. Exp. Med., 212(2):267-80.

7) Manes NP, Angermann BR1, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A. (2015) Targeted proteomics-driven computational modeling of macrophage S1P chemosensing. Mol. Cell. Proteomics, 14(10): 2661-81.

8) Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. (2015) Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J. Exp. Med. 212(11):1931-46.

9) Onodera T, Fukuhara A, Jang MH, Shin J, Aoi K, Kikuta J, Otsuki M, Ishii M, Shimomura I (2015) Adipose tissue macrophages induce PPARγ-high FOXP3+ regulatory T cells. Sci. Rep. 5:16801.

10) Ueta M, Koga A, Kikuta J, Yamada K, Kojima S, Ishii M, Kinoshita S. (2015) Intravital imaging of the cellular dynamics of LysM-positive cells in a corneal suture mouse model. Br. J. Opthalmol., 100: 432-5.

11) Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T. (2015) Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep., 6:18738.

12) Tiligada E, Ishii M, Riccardi C, Spedding M, Simon H-U, Teixeira MM, Cuervo MLC, Holgate ST, Levi-Schaffer F. (2015) The expanding role of immunopharmacology - IUPHAR Review X. Br. J. Pharmacol., 172(17): 4217-27.


2014年度

1) Simmons, Ishii M. (2014) Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. Arch. Immunol. Ther. Exp., 62(2); 103-115.

2) Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood N, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S. (2014) Lrig1 controls corneal maintenance through the Stat3-dependent inflammatory pathway. J. Clin. Invest, 124(1):385-97.

3) Nishikawa K, Iwamoto Y, Ishii M. (2014) Development of an in vitro culture method for stepwise differentiation of mouse embryonic stem cells and induced pluripotent stem cells into mature osteoclasts. J. Bone Miner. Metab., 32(3): 331-336.

4) Cuia G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K. (2014) Characterization of the Interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc. Natl. Acad. Sci. USA, 111(5):1915-20.

5) David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J. Biol. Chem., 289(10):6551-64.

6) Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. (2014) Integrin α9 on lymphatic endothelial cell regulates lymphocyte egress. Proc. Natl. Acad. Sci. USA, 118(8); 3080-3085.

7) Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A. (2014) A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J., 33(7): 702-18.

8) Rattanapak T, Birchall JC, Young K, Kubo A, Fujimori S, Ishii M, Hook S. (2014) Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS One, 9(2):e89503.

9) Matsui S, Murota H, Ono E, Kikuta J, Ishii M, Katayama I. (2014) Olopatadine hydrochloride restores histamine-induced impaired sweating. J. Dermatol. Sci., 74(3): 260-1.

10) Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. (2014) Generation of colonic IgA-secreting cells in the cecal patch. Nat. Commun., 5: 3704.

11) Hatori R, Ando T, Sasamura T, Nakazawa N, Nakamura M, Taniguchi K, Hozumi S, Kikuta J, Ishii M, Matsuno K. (2014) Left-right asymmetry is formed in individual cells by intrinsic cell chirality. Mech Dev., 133:146-62.

12) Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y. (2014) Filamin acts as a key regulator in epithelial defence against transformed cells. Nat. Commun., 5: 4428.

13) Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Umeshita K, Ishii H, Doki Y, Mori M, Ishii M. (2014) Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J. Biol. Chem., 289(34): 23786-23795.

14) Kikuta J, Ishii M. (2014) Intravital multiphoton microscopy for dissecting cellular dynamics in arthritic inflammation and bone destruction. Methods Mol. Biol.,1142: 1-10.


2013年度

1) Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M. (2013) Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. J. Immunol., 190(2):605-12.

2) Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamoto H, Doki Y, Mori M, Ishii H. (2013) Depletion of Jarid1b induces cellular senescence in human colorectal cancer. Int. J. Oncol., 42(4):1212-8.

3) Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. (2013) Dynamic visualization of RANKL and Th17-mediated osteoclast function. J. Clin. Invest., 123(2): 866-873.

4) Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci., 16(5):543-51.

5) Wienert S, Heim D, Kotani M, Lindequist B, Stenzinger A, Ishii M, Hufnagl P, Beil M, Dietel M, Denkert C, Klauschen F (2013) CognitionMaster: An Object-Based Image Analysis Framework. Diagn. Pathol., 8:34.

6) Ishii M, Kikuta J. (2013) Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. Biochim Biophys Acta, 1831(1), 223–227.

7) Kikuta J, Ishii M. (2013) Osteoclast migration, differentiation, and function: novel therapeutic targets for rheumatic diseases. Rheumatology, 52(2):226-34.

8) Ishii M, Fujimori S, Kaneko T, Kikuta J. (2013) Dynamic live imaging of bone: opening a new era with 'bone histodynametry'. J Bone Miner Metab, 31 (5): 507-511.

9) Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M (2013) S1P-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc. Natl. Acad. Sci. USA, 110(17): 7009-13.

10) Matsui S, Murota H, Takahashi A, Yang A, Lee J-B, Omiya K, Ohmi M, Kikuta J, Ishii M, Katayama I. (2014) Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J. Invest. Dermatol., 134(2): 326-34.

11) Rattanapak T, Birchall J, Young K, Ishii M, Meglinski I, Rades T, Hook S. (2013) Transcutaneous immunization using microneedles and cubosomes:  Mechanistic investigations using optical coherence tomography and two-photon microscopy. J. Control. Release, 172(3):894-903.

12) Kano Y, Konno M, Ohta K, Haraguchi N, Nishikawa S, Kagawa Y, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Ishii M, Mizohata E, Inoue T, Mori M, Doki Y, Ishii H. (2013) Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Mol Clin Oncol. 1(4):753-757.

13) Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M. (2013) Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One, 8(12): e83629.


2012年度以前の主な論文

1) Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M*, Mochizuki N* The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122: 1416-1426, 2012.

2) Kikuta J, Iwai K, Saeki Y, Ishii M. S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. Rheumatol. Int. 31: 967-969, 2011.

3) Kowada T, Kikuta, J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K. In vivo fluorescence imaging of bone-resorbing osteoclasts. J. Am. Chem. Soc., 33(44):17772-17776, 2011.

4) Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J. Exp. Med., 207: 2793-2796, 2010.

5) Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature, 458: 524-528, 2009.

6) Klauschen F, Ishii M, Qi, H., Bajénoff, M., Egen, J.G., Germain, R.N., Meier-Schellersheim, M. Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data. Nature Protoc., 4:1305-1311, 2009.