ホーム >> 主な発表論文

主な発表論文

 2023年

1)  Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y, Okuzaki D, Morii E, Emoto N, Shintan Y, Ishii M. (2023) In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nat. Commun., 14:143.

2) Yari S, Kikuta J, Shigyo H, Okuzaki D, Furusawa Y, Minoshima M, Kikushi K & Ishii M. (2023) JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors. Inflamm. Regen., 43(1):18

3) Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu YC, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara HIshii M. (2023) Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destructionNat. Commun., 14:4417.

4) Sudo T*, Yamashita E*, Kikuta J, Ishii M. (2023) Protocol for live imaging of transferred mouse bone marrow cells by two-photon microscopy. STAR Protoc.4(4):102654. *contributed equally 


 

 2022年

1) Uenaka M*, Yamashita E*, Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, Ishii M. (2022) Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nat. Commun., 13:1066. *contributed equally 

2) Narazaki A, Shimizu R, Yoshihara T, Kikuta J, Sakaguchi R, Tobita S, Mori Y, Ishii M, Nishikawa K. (2022) Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy. Sci. Rep. 12(1):3497.

3) Matsui T, Iwasa A, Mimura M, Taniguchi S, Sudo T, Uchida Y, Kikuta J, Morizono H, Horii R, Motoyama Y, Morii E, Ohno S, Kiyota Y, Ishii M. (2022) Label-free multiphoton excitation imaging as a promising diagnostic tool for breast cancer. Cancer Sci., 113(8):2916-2925.

4) Hasegawa T, Ishii M. (2022) Pathological Osteoclasts and Precursor Macrophages in Inflammatory Arthritis. Front Immunol. <Review>

5) Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. (2022) Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion. Inflamm Regen42(1):17. <Review>

6) Scheele CLGJ, Herrmann D, Yamashita E, Celso CL, Jenne CN, Oktay MH, Entenberg D, Friedl P, Weigert R, Meijboom FLB, Ishii M, Timpson P and Rheen JV. (2022) Multiphoton intravital microscopy of rodents. Nat Rev Methods Primers. 89.


 

 2021年

1) Morimoto A, Kikuta J, Nishikawa K, Sudo T, Uenaka M, Furuya M, Hasegawa T, Hashimoto K, Tsukazaki H, Seno S, Nakamura A, Okuzaki D, Sugihara F, Ninomiya A, Yoshimura T, Takao-Kawabata R, Matsuda H, Ishii M. (2021) SLPI is a critical mediator that controls PTH-induced bone formation. Nat. Commun., 2(1):2136.

2) Tsukazaki H, Kikuta J, Ao T, Morimoto A, Fukuda C, Tsuda E, Minoshima M, Kikuchi K, Kaito T, Ishii M. (2021) Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation. Bone, 152: 116095.

3) Nishikawa K, Seno S, Yoshihara T, Narazaki A, Sugiura Y, Shimizu R, Kikuta J, Sakaguchi R, Suzuki N, Takeda N, Semba H, Yamamoto M, Okuzaki D, Motooka D, Kobayashi Y, Suematsu M, Koseki H, Matsuda H, Yamamoto M, Tobita S, Mori Y, Ishii M. (2021) Osteoclasts adapt to physioxia perturbation through DNA demethylation. EMBO Rep., 22(12): e53035.

4) Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. (2021) Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis. Immunol. Med., 30, 1-5. <Review>

5) Hasegawa T, Kikuta J, Ishii M. (2021) Imaging of bone and joints in vivo: pathological osteoclastogenesis in arthritis. Int. Immunol., 33(12): 679-686. <Review>

6) Ao T, Kikuta J, Ishii M.(2021) The effects of vitamin D on immune system and inflammatory diseases. Biomolecules, 11:1624 <Review> 


 

 2020年

1) Nishizawa S, Kikuta J, Seno S, Kajiki M, Tsujita R, Mizuno H, Sudo T, Ao T, Matsuda H, Ishii M. (2020) Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo. J. Pharmacol. Sci., 143(1): 17-22.

2) Hashimoto K, Kaito T, Furuya M, Seno S, Okuzaki D, Kikuta J, Tsukazaki H, Matsuda H, Yoshikawa H, Ishii M. (2020) In vivo dynamic analysis of BMP-2-induced ectopic bone formation. Sci. Rep., 10(1):4751.

3) Ao T, Kikuta J, Sudo T, Uchida Y, Kobayashi K, Ishii M. (2020) Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation. Int. Immunol., 32(11):727-736.

4) Hasegawa T, Ishii M. (2020) Visualizing bone tissue in homeostatic and pathological conditions. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci., 96 (2), 43-49. <Review>

5) Morimoto A., Kikuta J., Ishii M. (2020) Intravital multiphoton microscopy as a novel tool in the field of immunopharmacology. Pharmacol. Ther., 206:107429. 

6) Morimatsu M, Yamashita E, Seno S, Sudo T, Kikuta J, Mizuno H, Okuzaki D, Motooka D, Ishii M. (2020) Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway. Inflamm. Regen., 6;40:15.

7) Hasegawa T, Kikuta J, Sudo T, Yamashita E, Seno S, Takeuchi T, Ishii M. (2020) Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo. Sci. Rep., 10;10(1):13480.

8) Matsui T, Tamoto R, Iwasa A, Mimura M, Taniguchi S, Hasegawa T, Sudo T, Mizuno H, Kikuta J, Onoyama I, Okugawa K, Shiomi M, Matsuzaki S, Morii E, Kimura T, Kato K, Kiyota Y, Ishii M. (2020) Nonlinear optics with near-infrared excitation enable real-time quantitative diagnosis of human cervical cancers. Cancer Res., 80(17):3745-3754.

9) Nishikawa K & Ishii M (2020) Novel method for gain-of-function analyses in primary osteoclasts using a non-viral gene delivery system. J Bone Miner Metab., published online.

10) Sudo T, Motomura Y, Okuzaki D, Hasegawa T, Yokota T, Kikuta J, Ao T, Mizuno H, Matsui T, Motooka D, Yoshizawa R, Nagasawa T, Kanakura Y, Moro K, Ishii M. (2020) Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. J. Exp. Med., 3;218(5):e20200817.


 

 2019年

1) Hasegawa T, Kikuta J, Ishii M. (2019) Imaging the Bone-Immune Cell Interaction in Bone Destruction. Front Immunol. 10:596. <Review>

2) Simmons S, Sasaki N, Umemoto E, Uchida Y, Fukuhara S, Kitazawa Y, Okudaira M, Inoue A, Tohya K, Aoi K, Aoki J, Mochizuki N, Matsuno K, Takeda K, Miyasaka M, Ishii M. (2019) High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node. Elife. 8. pii: e41239

3) Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M. (2019) Identification of a novel arthritis associated osteoclast precursor macrophage regulated by FoxM1. Nat Immunol. 20(12):1631-1643.


 

 2018年

1) Furuya M, Kikuta J, Fujimori S, Seno S, Maeda H, Shirazaki M, Uenaka M, Mizuno H, Iwamoto Y, Morimoto A, Hashimoto K, Ito T, Isogai Y, Kashii M, Kaito T, Ohba S, Chung Ui, Lichtler AC, Kikuchi K, Matsuda H, Yoshikawa H, Ishii M. (2018) Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo. Nat. Commun., 9(1):300.

2) Mizuno H, Kikuta J, Ishii M. (2018) In vivo live imaging of bone cells. Histochem. Cell Biol., 149(4): 417-422. <Review>

3) Matsumoto S, Kikuta J, Ishii M. (2018) Intravital imaging of liver cell dynamics. Methods Mol. Biol., 1763: 137-143

4) Kikuta J, Ishii M. (2018) Bone imaging: Osteoclast and osteoblast dynamics. Methods Mol. Biol., 1763: 137-143

5) Matsuura Y, Kikuta J, Kishi Y, Hasegawa T, Okuzaki D, Hirano T, Minoshima M, Kikuchi K, Kumanogoh A, Ishii M. (2018) In vivo visualization of different modes of action of biologic DMARDs inhibiting osteoclastic bone resorption. Ann. Rheum. Dis., 77(8):1219-1225.

6) Sakaguchi Y, Nishikawa K, Seno S, Matsuda H, Takayanagi H, Ishii M. (2018) Roles of enhancer RNAs in RANKL-induced osteoclast differentiation identified by genome-wide Cap-analysis of gene expression using CRISPR/Cas9. Sci. Rep., 14(1): 7504.

7) Kikuta J, Shirazaki M, Sudo T, Mizuno H, Morimoto A, Suehara R, Minoshima M, Kikuchi K, Ishii M. (2018) Dynamic analyses of the short-term effects of different bisphosphonates using intravital two-photon microscopy. JBMR Plus, 2(6): 362-366.


 

 2012~2017年

1) Matsui T, Mizuno H, Sudo T, Kikuta J, Haraguchi N, Ikeda JI, Mizushima T, Yamamoto H, Morii E, Mori M, Ishii M. (2017) Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions. Sci Rep., 31;7(1):6959. 

2) Ishii M. (2017) Imaging of inflammation and regeneration – a novel trend dissecting dynamic features of biological phenomena in vivo. Inflamm. Regen. 37: 26.

3) Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Ochi S, Penninger JM , Katayama I, Inohara I, Ishii M. (2016) Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Mol Cell Biol,  6(11):1610-20.

4) Takegahara N, Kim H, Mizuno H, Sakaue-Sawano A, Miyawaki A, Tomura M, Kanagawa O, Ishii M, Choi Y. (2016) Involvement of receptor activator of nuclear factor kappa-B ligand-induced incomplete cytokinesis in polyploidization of osteoclasts. J. Biol. Chem., 291: 3439-54.

5) Maeda H, Kowada T, Kikuta J, Furuya M, Shirazaki M, Mizukami S, Ishii M*, Kikuchi K*. (2016) Real-time intravital imaging of pH variation associated with cell osteoclast activity and motility using designed small molecular probe. Nature Chem. Biol., 12(8):579-85.

6) Otani K, Naito Y, Sakaguchi Y, Seo Y, Takahashi Y, Kikuta J, Ogawa K, Ishii M. (2016) Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo. Sci. Rep., 6:30689.

7) Sekimoto R, Fukuda S, Maeda N*, Tsushima Y, Matsuda K, Mori T, Nakatsuji H, Nishizawa H, Kishida K, Kikuta J, Maijima Y, Funahashi T, Ishii M*, Shimomura I. (2015) Visualized macrophage dynamics and significance of S100A8 in obese fat. Proc. Natl. Acad. Sci. USA, 112: E2058-66.

8) Sano H, Kikuta J, Furuya M, Kondo N, Endo N, Ishii M. (2015) Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo. Bone, 74:134-9.

9) Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M. (2015) RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. J. Biol. Chem., 290(10):6326-37.

10) Nishikawa K, Iwamoto Y, Kobayashi Y, Katsuoka F, Kawaguchi S, Tsujita T, Nakamura T, Kato S, Yamamoto M, Takayanagi H, Ishii M. (2015) Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway. Nature Med., 21(3):281-7.

11) Nishikawa K, Iwamoto Y, Ishii M. (2014) Development of an in vitro culture method for stepwise differentiation of mouse embryonic stem cells and induced pluripotent stem cells into mature osteoclasts. J. Bone Miner. Metab., 32(3): 331-336.

12) Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Umeshita K, Ishii H, Doki Y, Mori M, Ishii M. (2014) Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J. Biol. Chem., 289(34): 23786-23795.

13) Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M. (2013) Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. J. Immunol., 190(2):605-12.

14) Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. (2013) Dynamic visualization of RANKL and Th17-mediated osteoclast function. J. Clin. Invest., 123(2): 866-873.

15) Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M (2013) S1P-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc. Natl. Acad. Sci. USA, 110(17): 7009-13.

16) Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M. (2013) Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One, 8(12): e83629.


 

 2012年以前

1) Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M*, Mochizuki N* The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122: 1416-1426, 2012.

2) Kikuta J, Iwai K, Saeki Y, Ishii M. S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. Rheumatol. Int. 31: 967-969, 2011.

3) Kowada T, Kikuta, J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K. In vivo fluorescence imaging of bone-resorbing osteoclasts. J. Am. Chem. Soc., 33(44):17772-17776, 2011.

4) Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J. Exp. Med., 207: 2793-2796, 2010.

5) Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature, 458: 524-528, 2009.

6) Klauschen F, Ishii M, Qi, H., Bajénoff, M., Egen, J.G., Germain, R.N., Meier-Schellersheim, M. Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data. Nature Protoc., 4:1305-1311, 2009.